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Target intelligence / Profile preview
Serotonin 5-hydroxytryptamine receptor 1D (HTR1D)
- Target
- HTR1D
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
The serotonin 5-HT1D receptor (HTR1D) is a subtype of the serotonin receptor family and a G protein-coupled receptor (GPCR). It is primarily expressed in the central nervous system, influencing locomotion, anxiety behaviors, and cerebral blood vessel vasoconstriction. Activation leads to inhibition of adenylate cyclase and decreased cAMP levels. It is a therapeutic target for migraine.
- Other names
- 5-HT1D receptor
02
Mechanism of action
Agonists bind to the 5-HT1D receptor, coupled to Gi/Go proteins, leading to inhibition of adenylate cyclase, decreased cAMP levels, and an overall inhibitory cellular response. Functions as a terminal autoreceptor regulating serotonin release from nerve endings; thus modulating serotonergic neurotransmission. Antagonists block the receptor.
03
Biological functions
Signal transductionRegulation of neurotransmitter releaseVasoconstrictionModulation of locomotionModulation of anxiety behaviors
04
Disease associations
MigraineAnxiety disorders
05
Safety considerations
Vasoconstriction side effects with agonistsDifferential drug affinities across subtypes or species
06
Interacting drugs
Sumatriptan
2 more in the full profile.
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