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Target intelligence / Profile preview
Serotonin 5-hydroxytryptamine receptor 2C (5-HT2C)
- Target
- 5-HT2C
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor
01
Overview
The serotonin 5-HT2C receptor is a subtype of the serotonin (5-hydroxytryptamine, 5-HT) receptors, specifically within the 5-HT2 family. It is a GPCR that primarily couples to Gq/G11 proteins and mediates excitatory neurotransmission. The human gene encoding this receptor is HTR2C, located on the X chromosome. It plays significant roles in regulating mood, anxiety, feeding behavior, and reproductive behavior. Therapeutic interest includes drugs for obesity management, migraine treatment, psychiatric disorders, and substance use disorder therapies.
02
Mechanism of action
Modulates intracellular signaling cascades through Gq/G11-mediated pathways leading to increased intracellular calcium levels; Inhibition of dopamine and norepinephrine release
03
Biological functions
NeurotransmissionMood regulationAnxiety regulationFeeding behavior regulationReproductive behavior regulation
04
Disease associations
DepressionObsessive-compulsive disorder (OCD)Anxiety-related conditionsSubstance use disorders (SUD)ObesityPrader–Willi syndrome
05
Interacting drugs
Ergotamine
2 more in the full profile.
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