Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Serotonin 5-hydroxytryptamine receptor 5A (5-HT5A)
- Target
- 5-HT5A
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
Serotonin 5-hydroxytryptamine receptor 5A is a G protein-coupled receptor and one of the subtypes within the serotonin receptor family. Its primary function involves mediating the effects of serotonin in the central nervous system, contributing to signal transduction and neuronal regulation. The gene for 5-HT5A is functionally expressed in the human brain, while the related 5-HT5B subtype is non-functional in humans due to gene disruption. Although less studied than other serotonin receptors, 5-HT5A may be involved in modulating mood and cognitive functions, and experimental evidence suggests potential relevance to neurological and psychiatric disease, but it is not a major clinical drug target at present.
- Other names
- 5-HT5A receptorHTR5ASerotonin receptor 5A5-hydroxytryptamine receptor 5A
02
Mechanism of action
Antagonism or agonism at the receptor to modulate serotonin neurotransmission. Modulation of G protein signaling pathways
03
Biological functions
Signal transductionNeurotransmissionregulation of neuronal activity
04
Disease associations
While direct involvement in defined disease states is less extensively documented than for other serotonin receptors, 5-HT5A may play a role in neurological and psychiatric disorders
05
Interacting drugs
Limited clinical drugs target 5-HT5A specifically. Some experimental compounds (e.g. LSD, which acts broadly on serotonin receptors) may interact with it, but no major approved drugs target 5-HT5A exclusively
Beyond the preview
Go deeper on Serotonin 5-hydroxytryptamine receptor 5A (5-HT5A).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Serotonin 5-hydroxytryptamine receptor 5A (5-HT5A).