Target intelligence / Profile preview

Serotonin 5-hydroxytryptamine Receptor 6 (5HT6)

Target: 5HT6
Molecular classification: G protein-coupled receptor, GPCR, Receptor

Overview

The serotonin 5-HT6 receptor is a G protein-coupled receptor that binds serotonin and mediates excitatory neurotransmission via coupling to Gs proteins, leading to increased cAMP production. It is primarily expressed in the brain and is implicated in cognitive processes, motor control, and emotionality. It is a therapeutic target for cognitive impairment related to schizophrenia or Alzheimer’s disease.

Other names: 5-HT6 receptorHTR6Htr6

Mechanism of action

Activation of adenylate cyclase via Gs protein coupling, leading to increased intracellular cAMP levels.

Biological functions

Signal transductionModulation of neurotransmissionRegulation of cAMP levelsCognitive functionMemory formationMotor controlEmotional regulation

Disease associations

Alzheimer's diseaseParkinson's diseaseSchizophreniaCognitive impairmentNeuropsychiatric disorders

Safety considerations

Potential for off-target effects due to structural similarity with other GPCRsComplex role in multiple brain regions may lead to unintended consequencesLimited understanding of long-term effects of chronic modulation

Interacting drugs

SB742457

8 more in the full profile.

Biomarkers

rs1805054 (C267T polymorphism)

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