Serotonin 6 receptor and Adrenergic receptor (5-HT6 receptor and Adrenergic receptor)

The Serotonin 6 receptor (5-HT6 receptor) is a G protein-coupled receptor highly expressed in the central nervous system, where it modulates neurotransmission, cognition, learning, and mood, and is a therapeutic target for psychiatric and neurodegenerative disorders[1][3]. The Adrenergic receptors are a family of G protein-coupled receptors (including alpha and beta subtypes) that respond to catecholamines (epinephrine, norepinephrine) and mediate effects in the cardiovascular system, smooth muscle, metabolism, and central and peripheral nervous system. They are primary targets for drugs treating hypertension, heart failure, asthma, and anxiety disorders[3].

Other names

5-HT6 receptorAlpha-adrenergic receptorBeta-adrenergic receptorAdrenoceptor

Serotonin 6 receptor: Agonism or antagonism, usually CNS-selective, leading to modulation of cAMP signaling via Gs protein coupling, affecting cognition, mood, feeding. Adrenergic receptors: Agonism or antagonism, modulating G protein-coupled signaling (Gs, Gi/o, Gq/11) to affect heart rate, vascular tone, smooth muscle contraction/relaxation, neurotransmitter release