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Target intelligence / Profile preview
Serotonin 7 Receptor (5-HT7)
- Target
- 5-HT7
- Molecular classification
- G protein-coupled receptor
01
Overview
The serotonin 7 receptor (5-HT7) is a G protein-coupled receptor activated by serotonin. It plays a crucial role in various physiological processes, including mood regulation, circadian rhythms, learning, memory, and synaptic plasticity. Dysregulation of 5-HT7 is implicated in several disorders, including depression, neurocognitive disorders, irritable bowel syndrome, and neurodevelopmental diseases, making it a target for drug development.
- Other names
- Serotonin receptor 75-hydroxytryptamine receptor 7HTRVIISROD9
02
Mechanism of action
Agonist or antagonist binding to the 5-HT7 receptor, modulating downstream signaling pathways such as cAMP/PKA and RhoA/Cdc42.
03
Biological functions
Signal transductionMood regulationCircadian rhythm/sleep controlLearning/memorySynaptic plasticitySmooth muscle relaxationRegulation of thermoregulation
04
Disease associations
DepressionMild neurocognitive disorderIrritable bowel syndromeNeurodevelopmental diseases
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