Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Serotonin and Noradrenaline Reuptake (SNRI Target)
- Target
- SNRI Target
- Molecular classification
- Transporter, Membrane Transport Protein
01
Overview
Serotonin and noradrenaline reuptake refers to the biological process by which the neurotransmitters serotonin (5-HT) and noradrenaline (NE) are transported from the synaptic cleft back into presynaptic neurons via SERT and NET transporters. Inhibition of these transporters is the mechanism of action of SNRIs, leading to increased synaptic concentrations of these neurotransmitters and enhanced signaling. This target is central to modern antidepressant and anxiolytic therapy.
- Other names
- 5-HT and NE ReuptakeSerotonin-Norepinephrine TransportersSERT and NET InhibitionDual Reuptake Inhibition
02
Mechanism of action
Inhibition of serotonin (SERT) and noradrenaline (NET) transporters, leading to increased extracellular concentrations of serotonin and noradrenaline in the synaptic cleft and enhanced postsynaptic receptor activation.
03
Biological functions
Neurotransmitter reuptakeSynaptic neurotransmitter clearanceRegulation of monoamine levelsModulation of neurotransmission
04
Disease associations
DepressionAnxiety disordersPain disordersFibromyalgia
05
Safety considerations
Increased blood pressureSerotonin syndrome (with concomitant serotonergic agents)Withdrawal symptoms upon discontinuationSuicidal ideation (in some patient populations)Gastrointestinal side effectsSexual dysfunction
06
Interacting drugs
Venlafaxine
4 more in the full profile.
07
Biomarkers
Plasma levels of serotonin and noradrenalineGenetic polymorphisms in SERT and NET genesNeuroimaging studies (e.g., PET scans) assessing SERT and NET occupancy
Beyond the preview
Go deeper on Serotonin and Noradrenaline Reuptake (SNRI Target).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Serotonin and Noradrenaline Reuptake (SNRI Target).