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Target intelligence / Profile preview
Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)
- Target
- SNRI
- Molecular classification
- Pharmaceutical, Antidepressant
01
Overview
Serotonin-norepinephrine reuptake inhibitors (SNRIs) are a class of medications that inhibit the reabsorption (reuptake) of serotonin and norepinephrine in the brain. This action increases the levels of these neurotransmitters in the synaptic cleft, enhancing their activity and leading to improved mood regulation and pain relief. SNRIs are primarily used as antidepressants and for the treatment of anxiety disorders and chronic pain conditions.
- Other names
- SNRIsDual reuptake inhibitorsSerotonin and norepinephrine transporter inhibitors
02
Mechanism of action
Inhibits the reuptake of serotonin and norepinephrine by blocking the serotonin transporter (SERT) and norepinephrine transporter (NET), respectively, leading to increased levels of these neurotransmitters in the synaptic cleft.
03
Biological functions
Mood regulationPain modulationNeurotransmitter regulation
04
Disease associations
DepressionAnxiety disordersChronic painNeuropathic pain
05
Safety considerations
Gastrointestinal upsetIncreased blood pressureIncreased heart ratePotential for serotonin syndrome when combined with other serotonergic agentsWithdrawal symptoms upon discontinuation
06
Interacting drugs
Venlafaxine
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