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Target intelligence / Profile preview
Serotonin-Norepinephrine Transporter (SERT/NET)
- Target
- SERT/NET
- Molecular classification
- Transporter, Solute Carrier Family SLC6, Neurotransmitter Sodium Symporter (NSS)
01
Overview
The Serotonin-Norepinephrine Transporter collectively refers to the serotonin transporter (SERT) and norepinephrine transporter (NET), integral membrane proteins responsible for the reuptake of serotonin and norepinephrine, respectively, from the synaptic cleft. They play a critical role in regulating neurotransmission and are major targets for antidepressant drugs. Genetic variations and dysregulation are implicated in various neuropsychiatric and cardiovascular disorders.
- Other names
- Serotonin Transporter/SERTNorepinephrine Transporter/NETNoradrenaline TransporterSLC6A4/SLC6A2
02
Mechanism of action
Inhibition of serotonin and/or norepinephrine reuptake
03
Biological functions
Neurotransmitter reuptakeRegulation of synaptic neurotransmitter concentrationMonoamine homeostasis
04
Disease associations
DepressionAnxiety DisordersADHDChronic Pain SyndromesPanic DisorderPostural Orthostatic Tachycardia SyndromeCardiovascular DiseaseNeurodevelopmental Disorders
05
Safety considerations
Serotonin SyndromeNoradrenergic side effects (e.g., increased blood pressure, heart rate)Drug interactionsDownregulation of transporter expression with chronic use
06
Interacting drugs
Tricyclic Antidepressants (TCAs)
9 more in the full profile.
07
Biomarkers
rs5569 in SLC6A2SLC6A4 SNPsPromoter methylation status of SLC6A2/SLC6A4
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