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Target intelligence / Profile preview
Serotonin Plasma Membrane Transport Protein (SERT)
- Target
- SERT
- Molecular classification
- Transporter, Solute carrier family 6 member 4, Monoamine transporter family
01
Overview
The serotonin plasma membrane transport protein (SERT), encoded by the SLC6A4 gene, is responsible for the reuptake of serotonin from the synaptic cleft into presynaptic neurons. This process terminates serotonergic signaling and recycles serotonin. SERT is a target for antidepressant drugs like SSRIs and tricyclic antidepressants. Genetic variations in SLC6A4 are associated with various psychiatric conditions.
- Other names
- 5-HTTSodium-dependent serotonin transporter
02
Mechanism of action
Inhibition of serotonin reuptake, leading to increased extracellular serotonin levels
03
Biological functions
Serotonin reuptakeRegulation of serotonergic neurotransmissionSerotonin homeostasis
04
Disease associations
DepressionAnxiety disordersPost-traumatic stress disorder (PTSD)Sudden infant death syndrome (SIDS)Aggressive behavior in Alzheimer’s diseaseSubstance use disorders
05
Interacting drugs
Selective Serotonin Reuptake Inhibitors (SSRIs)
1 more in the full profile.
06
Biomarkers
SLC6A4 polymorphisms
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