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Target intelligence / Profile preview
Serotonin receptor (5-HT receptor)
- Target
- 5-HT receptor
- Molecular classification
- G protein-coupled receptor, Ligand-gated ion channel, Receptor
01
Overview
Serotonin receptors, also known as 5-HT receptors, are a family of G protein-coupled receptors and ligand-gated ion channels that mediate the diverse effects of the neurotransmitter serotonin. They are widely distributed throughout the central and peripheral nervous systems and regulate a vast array of physiological and behavioral processes, making them important therapeutic targets for a variety of disorders.
- Other names
- 5-hydroxytryptamine receptor
02
Mechanism of action
Agonism, antagonism, or partial agonism at serotonin receptor subtypes, leading to modulation of downstream signaling pathways. For 5-HT3 receptors, drugs can act as channel blockers, preventing cation influx.
03
Biological functions
Mood regulationAnxiety regulationAppetite controlCognitionMemorySleep-wake cycle regulationThermoregulationHormone releaseGastrointestinal motilityBlood clottingPain perceptionSexual desireNeurotransmission
04
Disease associations
DepressionAnxiety disordersSchizophreniaMigraineFibromyalgia
05
Safety considerations
Serotonin syndromeCardiac effects (e.g., QT prolongation)Drug interactionsSide effects specific to individual receptor subtypes and drugs
06
Interacting drugs
SSRIs
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