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Serotonin Receptor 1A Subunit (5-HT1A)
- Target
- 5-HT1A
- Molecular classification
- G protein-coupled receptor, GPCR, Class A Rhodopsin-like
01
Overview
The serotonin receptor 1A subunit (5-HT1A receptor) is a G protein-coupled receptor that binds serotonin. It is widely distributed in the brain and peripheral tissues and plays a crucial role in mood, anxiety, cognition, sleep, and pain regulation. As both an autoreceptor and heteroreceptor, it modulates serotonin release and neuronal excitability. It is a key target for antidepressant and anxiolytic drugs.
- Other names
- Serotonin receptor 1A5-hydroxytryptamine receptor 1A
02
Mechanism of action
Agonism, partial agonism, or antagonism of the 5-HT1A receptor, leading to modulation of neuronal excitability and neurotransmitter release.
03
Biological functions
Signal transductionMood regulationAnxiety controlCognitionSleep regulationPain modulationDopaminergic modulation
04
Disease associations
Anxiety disordersDepressionSchizophreniaOther psychiatric disorders
05
Safety considerations
Serotonin syndrome (with concurrent serotonergic agents)DizzinessNauseaFatigue
06
Interacting drugs
Antidepressants (SSRIs, SNRIs)
4 more in the full profile.
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