Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Serotonin Receptor 1B Subunit (5-HT1B)
- Target
- 5-HT1B
- Molecular classification
- G protein-coupled receptor, GPCR, Class A GPCR, Family A GPCR, Receptor
01
Overview
The serotonin receptor 1B subunit (5-HT1B) is a G protein-coupled receptor that binds serotonin and is primarily located on presynaptic axon terminals. It functions as an autoreceptor to inhibit serotonin release and as a heteroreceptor to modulate the release of other neurotransmitters. Its activation influences mood, cognition, appetite, aggression, anxiety, pain, and vascular tone. It is implicated in psychiatric disorders like depression and is a target for antimigraine drugs.
- Other names
- 5-hydroxytryptamine receptor 1B
02
Mechanism of action
Presynaptic inhibition of neurotransmitter release via Gi/o protein activation and adenylyl cyclase inhibition.
03
Biological functions
Neurotransmitter release inhibitionModulation of neurotransmitter releaseSynaptic transmission regulationSignal transduction
04
Disease associations
DepressionMigraineMood disordersAnxiety
05
Safety considerations
Potential for vasoconstriction (e.g., ergotamine)Off-target effects due to sequence homology with other serotonin receptors
06
Interacting drugs
Serotonin
2 more in the full profile.
Beyond the preview
Go deeper on Serotonin Receptor 1B Subunit (5-HT1B).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Serotonin Receptor 1B Subunit (5-HT1B).