Target intelligence / Profile preview

5-hydroxytryptamine receptor 1D (HTR1D)

Target: HTR1D
Molecular classification: G protein-coupled receptor (GPCR), Receptor, Serotonin receptor

Overview

The 5-hydroxytryptamine receptor 1D (HTR1D) is a G protein-coupled receptor for serotonin that mediates inhibitory neurotransmission. It is primarily known for its role in migraine pathophysiology, where triptans act as agonists to induce vasoconstriction. It is expressed in brain regions, including the basal ganglia, hippocampus, and cortex, and in vascular smooth muscle cells.

Other names: Serotonin receptor 1D5-HT1D receptor

Mechanism of action

Triptans act as agonists at both 5-HT₁B and 5-HT₁D receptors, leading to vasoconstriction of cerebral blood vessels, inhibition of vasoactive neuropeptide release, and suppression of nociceptive neurotransmission.

Biological functions

Neurotransmission modulationRegulation of neurotransmitter releaseVasoconstrictionModulation of locomotionModulation of anxiety

Disease associations

Migraine

Interacting drugs

Sumatriptan

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