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Target intelligence / Profile preview
Serotonin receptor 1E (5-HT1E)
- Target
- 5-HT1E
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
The serotonin receptor 1E (5-HT1E) is a Gi/o-coupled G protein-coupled receptor primarily expressed in the frontal cortex, hippocampus, olfactory bulb, caudate putamen, and amygdala in humans. Activation inhibits adenylate cyclase, decreasing cAMP levels. Its precise physiological function is still unclear due to the lack of selective pharmacological tools and animal models (absent in rodents). Hypothesized roles include memory regulation, neuroprotection, immune modulation, and involvement in cell survival pathways, including potential links to cancer progression. There are currently no approved drugs targeting specifically the human serotonin receptor 1E.
- Other names
- 5HT1EHTR1E
02
Mechanism of action
Gi/o protein-coupled receptor; inhibits adenylate cyclase activity, leading to decreased cAMP levels.
03
Biological functions
Signal transductionInhibition of adenylate cyclasePossible memory regulationPossible neuroprotectionPossible immune modulationCell survival
04
Disease associations
Possible role in cancer progression
05
Safety considerations
Lack of selective pharmacological toolsInsufficient understanding of function
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