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Target intelligence / Profile preview
Serotonin Receptor 2C (5-HT2C)
- Target
- 5-HT2C
- Molecular classification
- G protein-coupled receptor (GPCR), Class A GPCR, Serotonin receptor
01
Overview
The serotonin 5-HT2C receptor is a G protein-coupled receptor that binds serotonin and modulates various physiological processes, including neurotransmitter release, mood, anxiety, feeding behavior, and reproductive behavior. It is a therapeutic target for CNS disorders, including obesity, depression/anxiety spectrum disorders, sexual dysfunctions, and urinary issues. Development of selective agonists has been challenging, and off-target effects remain a concern.
- Other names
- 5-hydroxytryptamine receptor 2CHTR2C
02
Mechanism of action
Modulates neuronal activity via G protein signaling pathways; inhibits dopamine and norepinephrine release in certain brain areas.
03
Biological functions
Neurotransmitter release regulationMood regulationAnxiety controlFeeding behavior/satiety signalingReproductive behaviorModulation of pituitary hormone release (ACTH & prolactin)
04
Disease associations
ObesityDepressionAnxiety disordersSexual dysfunctionSleep disturbanceUrinary issues
05
Safety considerations
Lack of selectivity over closely related subtypes (5‑HT₂A/₂B)Hallucinations (from 5HT2A)Cardiac valvulopathy (from 5HT2B)
06
Interacting drugs
Serotonin
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