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Target intelligence / Profile preview
Serotonin receptor 2D (5-HT₂ᴰ)
- Target
- 5-HT₂ᴰ
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor, Type II serotonergic GPCR
01
Overview
The serotonin receptor 2D (5-HT₂ᴰ) is a putative member of the serotonin receptor family. It is a G protein-coupled receptor that signals primarily via the Gq/11-PLC-Ca²⁺ pathway. While a distinct human gene or protein for '5-HT2D' is not well-established and most research focuses on 5-HT2A, 5-HT2B, and 5-HT2C, it is inferred to be involved in neurotransmitter release, mood regulation, and cardiovascular function based on the roles of related subtypes.
- Other names
- 5HT2D receptorSerotonin type 2D receptor
02
Mechanism of action
Gq/11-PLC-Ca²⁺ signaling pathway activation
03
Biological functions
Signal transductionModulation of neurotransmitter releaseRegulation of mood/emotionVascular smooth muscle contractionPlatelet aggregation
04
Disease associations
Neurological disordersMood disordersCardiovascular disease
05
Safety considerations
Potential for off-target effects due to similarity with other serotonin receptor subtypesLimited data on specific effects of targeting this receptor
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