5-hydroxytryptamine receptor 3A (5-HT3A)

The 5-hydroxytryptamine receptor 3A (5-HT3A) is a subunit of the type 3 serotonin receptor, a ligand-gated ion channel mediating fast excitatory neurotransmission in both the central and peripheral nervous systems. Upon activation by serotonin, it forms a cation-selective channel allowing rapid influx of sodium, potassium, and calcium ions, resulting in neuronal depolarization. It is a target for antiemetic drugs like ondansetron and granisetron, and is implicated in psychiatric disorders such as major depressive disorder and PTSD.

Other names

Serotonin-gated ion channel receptorSerotonin receptor 3AHTR3HTROE

Activation by serotonin leads to opening of the cation-selective ion channel, resulting in rapid influx of Na+, K+, and Ca2+ ions and subsequent depolarization. Antagonists block the channel, preventing ion flow and inhibiting neurotransmission.