Target intelligence / Profile preview

Serotonin Receptor 3A Subunit (5-HT3A)

Target: 5-HT3A
Molecular classification: Ligand-gated ion channel, Receptor, Cys-loop receptor superfamily

Overview

The serotonin receptor 3A subunit (5-HT3A), encoded by the HTR3A gene, is a subunit of the type 3 serotonin receptor, a ligand-gated ion channel. It mediates neuronal excitation upon serotonin binding and is a key target for antiemetic drugs.

Other names: 5-hydroxytryptamine receptor 3AHTR3A

Mechanism of action

Ligand-gated ion channel blockade; prevents serotonin binding and subsequent neuronal depolarization.

Biological functions

NeurotransmissionGut motility regulationNeuronal excitationNeurodevelopment

Disease associations

AnxietyIrritable Bowel SyndromeEmesis

Safety considerations

QT interval prolongation (for some setrons)Constipation (alosetron)

Interacting drugs

Serotonin

4 more in the full profile.

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