Target intelligence / Profile preview

Serotonin Receptor 5-HT₂A (None)

Target: None
Molecular classification: G protein-coupled receptor (GPCR), Seven-transmembrane domain receptor, Receptor

Overview

The serotonin 2A receptor (5-HT₂A) is a subtype of the serotonin receptor family and a G protein-coupled receptor (GPCR). It is the main excitatory GPCR for serotonin in the central nervous system, coupled to Gq/11 proteins and activating the PLC/IP3/DAG pathway. It is highly expressed in cortical regions and plays a critical role in cognition, mood regulation, and mediating the effects of hallucinogens. It's also implicated in neuropsychiatric disorders like depression and schizophrenia and targeted by antipsychotic drugs.

Other names: 5-HT2A ReceptorSerotonin 2A Receptor5-Hydroxytryptamine Receptor 2AHTR2A

Mechanism of action

Agonism induces altered perception/cognition via enhanced cortical neuron plasticity. Antagonism results in antipsychotic/antidepressant effects.

Biological functions

Excitatory neurotransmissionCognitionMood regulationVascular toneSignal transductionNeurotransmitter release modulationNeuronal excitability modulationSynaptic plasticity modulationNeurogenesisPlatelet aggregation regulation

Disease associations

DepressionSchizophreniaNeuropsychiatric disorders

Safety considerations

HallucinationsAltered perceptionCognitive impairmentCardiovascular effects (vasoconstriction, platelet aggregation)

Interacting drugs

Serotonin

4 more in the full profile.

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