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Serotonin Receptor 5-HT1A (None)
- Target
- None
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
The serotonin 1A receptor (5-HT1A) is a subtype of serotonin receptors and a G protein-coupled receptor (GPCR) coupled to Gi/o proteins. It is widely expressed in the brain, particularly in the cerebral cortex, hippocampus, septum, amygdala, and raphe nucleus. Functioning as both an autoreceptor on serotonergic neurons in the raphe nuclei and as a postsynaptic heteroreceptor in target brain regions, it plays a key role in modulating mood, anxiety, cognition, and hormone secretion. Activation of the receptor leads to hyperpolarization and inhibition of neuronal firing, making it a therapeutic target for anxiety disorders and depression.
- Other names
- Serotonin receptor 1A5-hydroxytryptamine receptor 1AG-21ADRBRL1ADRB2RL15-HT1A
02
Mechanism of action
Activation of Gi/o proteins, inhibition of adenylyl cyclase, decrease in cAMP production, opening of potassium channels, hyperpolarization of neurons, inhibition of calcium channels, reduction of neurotransmitter release.
03
Biological functions
Signal transductionModulation of neuronal excitabilityRegulation of hormone secretionModulation of moodModulation of anxietyModulation of cognition
04
Disease associations
Anxiety disordersDepressionCognitive dysfunction
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