Serotonin Receptor 5-HT1A Subtype (5-HT1A)

The serotonin 1A receptor (5-HT1A) is a subtype of serotonin (5-hydroxytryptamine, 5-HT) receptors. It is a G protein-coupled receptor (GPCR), specifically coupled to Gi/Go proteins, and plays a key role in mediating the effects of serotonin in the central nervous system and peripheral tissues. In humans, it is encoded by the HTR1A gene. It regulates mood and behavior, neurotransmitter release and hormone secretion and is implicated in mood disorders such as major depressive disorder.

Other names

Serotonin 1A receptor5-hydroxytryptamine receptor 1AHTR1A receptor

Agonism or antagonism of 5-HT1A receptor modulating neuronal activity through Gi/Go protein coupling and subsequent downstream signaling pathways (e.g., inhibition of adenylyl cyclase, activation of potassium channels).