Target intelligence / Profile preview

Serotonin Receptor 5-HT1D (5-HT1D)

Target: 5-HT1D
Molecular classification: G protein-coupled receptor

Overview

The serotonin receptor 5-HT1D (HTR1D) is a G protein-coupled receptor that binds serotonin and modulates various physiological functions, including neurotransmitter release, locomotion, anxiety, and cerebral vasoconstriction. It is a target for antimigraine drugs like sumatriptan.

Other names: HTR1D

Mechanism of action

Gi/o-mediated inhibition of adenylyl cyclase, leading to decreased intracellular cAMP levels

Biological functions

Signal transductionAutoreceptor regulationRegulation of locomotionRegulation of anxietyCerebral vasoconstriction

Disease associations

MigraineAnxiety disorders

Safety considerations

Potential for vasoconstriction-related side effects

Interacting drugs

Sumatriptan

2 more in the full profile.

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