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Target intelligence / Profile preview
Serotonin Receptor 5-HT2 (5-HT2)
- Target
- 5-HT2
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor
01
Overview
The serotonin receptor 5-HT2 refers to a subfamily of serotonin (5-hydroxytryptamine, 5-HT) receptors. These are G protein-coupled receptors (GPCRs) that bind the endogenous neurotransmitter serotonin. The main subtypes in this family are 5-HT2A, 5-HT2B, and 5-HT2C. They couple primarily to Gq/G11 proteins, leading to stimulation of phospholipase C (PLC), increased intracellular calcium levels, and activation of protein kinase C pathways. Involved in cognition, mood regulation, neurotransmission, vascular tone, and inflammation. Target for hallucinogens and many psychiatric drugs. Abnormal function is implicated in psychiatric disorders.
- Other names
- 5-hydroxytryptamine receptor 25-HT2 receptor family
02
Mechanism of action
Agonism at 5-HT2A receptor (hallucinogens); Antagonism at 5-HT2 receptors (antipsychotics)
03
Biological functions
Signal transductionCognitionMood regulationNeurotransmissionVascular tone regulationInflammationWound healingPlatelet aggregation
04
Disease associations
DepressionSchizophreniaDrug addictionPsychosis
05
Safety considerations
Hallucinations (agonists)Downregulation/adaptive changes with chronic SSRI/antipsychotic use
06
Interacting drugs
LSD
4 more in the full profile.
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