Serotonin Receptor 5-HT2A (5-HT2A)

The serotonin 2A receptor (5-HT2A) is a G protein-coupled receptor that mediates excitatory neurotransmission in the central nervous system. It is involved in various physiological functions, including learning, memory, mood regulation, and perception. The receptor is implicated in psychiatric disorders such as depression and schizophrenia and is a target for psychedelic drugs, antipsychotics, and antidepressants. Activation by agonists leads to increased intracellular calcium and PKC activation, while antagonists block the receptor and prevent serotonin binding.

Other names

Serotonin 2A receptor5-hydroxytryptamine receptor 2AHTR2A

Agonists (e.g., LSD, psilocybin) activate the receptor, leading to increased intracellular calcium and PKC activation. Antagonists (e.g., atypical antipsychotics) block the receptor, preventing serotonin binding and downstream signaling.