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Target intelligence / Profile preview
Serotonin Receptor 5-HT2C (5-HT2C receptor)
- Target
- 5-HT2C receptor
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
The 5-HT2C receptor is a G protein-coupled receptor (GPCR) that primarily couples to the Gq/G11 protein and mediates excitatory neurotransmission. It plays significant roles in regulating mood, anxiety, feeding behavior, and reproductive behavior. It also modulates dopamine release across several brain regions. Genetic variations are associated with susceptibility to psychiatric disorders, substance use disorders, and obesity. Drugs targeting the 5-HT2C receptor are used or investigated for treating obesity, drug abuse, and schizophrenia. Antagonists can stimulate dopaminergic pathways, potentially useful for counteracting SSRI-induced side effects or treating Parkinson’s disease. The receptor interacts with proteins such as MPDZ, which may influence its signaling properties.
- Other names
- 5-hydroxytryptamine receptor 2CHTR2C
02
Mechanism of action
Agonism, antagonism, inverse agonism, allosteric modulation, depending on the drug and region of the brain.
03
Biological functions
NeurotransmissionMood regulationAppetite controlFeeding behaviorReproductive behaviorDopamine modulation
04
Disease associations
DepressionAnxiety disordersObsessive-compulsive disorderSubstance use disorderObesitySchizophreniaParkinson's diseasePrader–Willi syndrome
05
Safety considerations
SSRI-induced side effectsParadoxical behavioral outcomes depending on regional selectivity
06
Interacting drugs
Ergotamine
2 more in the full profile.
07
Biomarkers
HTR2C polymorphisms (associated with susceptibility to psychiatric disorders, substance use disorders, obesity)
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