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Target intelligence / Profile preview
Serotonin Receptor 5-HT4 (5-HT4)
- Target
- 5-HT4
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor
01
Overview
The serotonin receptor 5-HT4 is a G protein-coupled receptor that mediates various physiological processes in both the central and peripheral nervous systems. It is involved in neurotransmitter modulation, regulation of gastrointestinal motility, and modulation of appetite and feeding behavior. Clinically, it is targeted by drugs such as prucalopride, renzapride, and felcisetrag to treat conditions like chronic idiopathic constipation and constipation-predominant IBS.
- Other names
- 5-Hydroxytryptamine Receptor 4HTR4
02
Mechanism of action
Agonist of 5-HT4 receptor, stimulating intestinal peristalsis via activation of enteric neuronal circuits.
03
Biological functions
Neurotransmitter modulationRegulation of gastrointestinal motilityModulation of appetite and feeding behaviorSignal transduction
04
Disease associations
Chronic idiopathic constipationConstipation-predominant IBSGastroesophageal reflux disease (GERD)GastroparesisMood disorders
05
Interacting drugs
Prucalopride
3 more in the full profile.
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