Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Serotonin Receptor 5-HT6 (5-HT6R)
- Target
- 5-HT6R
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
The serotonin receptor 5-HT6 (5-HT6R) is a G protein-coupled receptor primarily expressed in the brain. It binds serotonin and modulates the activity of other neurotransmitter systems, including glutamate, acetylcholine, dopamine, norepinephrine, and GABA. It is implicated in cognitive and psychiatric disorders and is a target for drug development for Alzheimer's disease, schizophrenia, depression, anxiety, OCD, and obesity.
- Other names
- 5-hydroxytryptamine receptor 65HT6 receptor
02
Mechanism of action
Gs protein activation, increased cAMP production, modulation of neurotransmitter release (glutamate, acetylcholine, dopamine, norepinephrine, GABA)
03
Biological functions
Signal transductionNeurotransmitter modulationRegulation of neurotransmitter releaseModulation of adenylate cyclase activitycAMP production
04
Disease associations
Alzheimer's diseaseCognitive disordersPsychiatric disordersSchizophreniaDepressionAnxietyObsessive-compulsive disorder (OCD)Obesity
05
Safety considerations
Clinical trial failures despite promising preclinical data for Alzheimer's diseasePotential for indirect effects on other neurotransmitter systemsParadoxical effects of agonists and antagonists
06
Interacting drugs
Serotonin
6 more in the full profile.
Beyond the preview
Go deeper on Serotonin Receptor 5-HT6 (5-HT6R).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Serotonin Receptor 5-HT6 (5-HT6R).