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Target intelligence / Profile preview
Serotonin Receptor 5-HT7 (5-HT7)
- Target
- 5-HT7
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
The serotonin receptor 5-HT7 (HTR7) is a G protein-coupled receptor activated by serotonin. It is broadly expressed in the brain and peripheral tissues, mediating diverse functions including circadian rhythm regulation, mood control, cognition, and smooth muscle relaxation. It is implicated in various diseases, including depression, cognitive disorders, and irritable bowel syndrome, and is being explored as a therapeutic target.
- Other names
- HTR75-hydroxytryptamine Receptor 7Serotonin type VII ReceptorGPCR XSerotonin Receptor 7
02
Mechanism of action
Agonism leads to activation of adenylate cyclase and increased cAMP levels; antagonism blocks serotonin binding and downstream signaling.
03
Biological functions
Signal transductionRegulation of circadian rhythmSleep regulationMood regulationCognitive functionNociception/pain processingSmooth muscle relaxation
04
Disease associations
DepressionMild neurocognitive disorderSchizophrenia-related cognition deficitsIrritable bowel syndromeTriple-negative breast cancerEpilepsyMigraineAutism spectrum disordersRett Syndrome
05
Safety considerations
Clinical efficacy of selective antagonists for depression remains under investigation.
06
Biomarkers
Expression levels in triple-negative breast cancer may be a prognostic factor.
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