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Target intelligence / Profile preview
Serotonin Receptor 5A (5-HT5A)
- Target
- 5-HT5A
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
The serotonin receptor 5A (5-HT5A) is a G protein-coupled receptor that binds serotonin and is primarily expressed in the central nervous system. It couples mainly to Gi/Go proteins, leading to inhibition of adenylyl cyclase activity and decreased intracellular cAMP levels and also regulates intracellular calcium mobilization. It's involved in modulating neurotransmission, neural plasticity, and may serve as a presynaptic serotonin autoreceptor. No well-established drugs specifically target this receptor, but there are known active ligands.
- Other names
- HTR5A5-hydroxytryptamine receptor 5ASerotonin receptor 5AMR22
02
Mechanism of action
Gi/Go protein-coupled receptor, inhibition of adenylyl cyclase activity, decreased intracellular cAMP levels, regulation of intracellular calcium mobilization
03
Biological functions
Signal transductionModulating neurotransmissionNeural plasticityPresynaptic serotonin autoreceptor
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