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Target intelligence / Profile preview
Serotonin receptor 5HT1A (5-HT1A)
- Target
- 5-HT1A
- Molecular classification
- G protein-coupled receptor (GPCR), Class A GPCR, Receptor
01
Overview
The Serotonin Receptor 5HT1A is a Gi/o-coupled GPCR encoded by HTR1A with widespread CNS distribution. It functions both presynaptically as an autoreceptor regulating serotonergic tone via negative feedback mechanisms—and postsynaptically modulating neuronal excitability across multiple brain regions involved in emotion/mood regulation. Its pharmacological targeting underlies several therapeutic strategies for mood/anxiety disorders due to its central role in emotional balance.
- Other names
- Serotonin 1A receptor5HT1A receptor5-HT1A receptor
02
Mechanism of action
Agonists, partial agonists, or antagonists modulate the activity of the 5-HT1A receptor, influencing downstream signaling pathways involving adenylyl cyclase inhibition, potassium channel activation, and calcium channel inactivation. This leads to changes in neuronal excitability and serotonergic neurotransmission.
03
Biological functions
Signal transductionRegulation of neuronal excitabilityRegulation of serotonin releaseModulation of hormone secretion
04
Disease associations
Major depressive disorder (MDD)Anxiety disordersMood regulationCognitive/emotional processing
05
Interacting drugs
Buspirone
2 more in the full profile.
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