Serotonin Receptor 5HT1D (None)

The serotonin receptor 5HT1D (5-HT1D, HTR1D) is a subtype of the serotonin receptor family. It is a G protein-coupled receptor (GPCR) that mediates inhibitory neurotransmission by decreasing cellular levels of cyclic AMP (cAMP). It functions primarily in the modulation of neurotransmitter release, particularly serotonin, and is involved in vasoconstriction. Drugs targeting this receptor, such as triptans, are used for acute migraine therapy. Dysfunctions involving this receptor have been implicated in mood disorders including depression and anxiety.

Other names

5-hydroxytryptamine receptor 1DHTR1DSerotonin receptor 1DRDC4S12

Agonists induce cranial vasoconstriction and inhibit neuropeptide release from trigeminal nerve endings; antagonists block serotonin binding and downstream signaling.