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Target intelligence / Profile preview
Serotonin Receptor 5HT3 (5-HT3 Receptor)
- Target
- 5-HT3 Receptor
- Molecular classification
- Ligand-gated ion channel, Receptor, Cys-loop receptor
01
Overview
The serotonin receptor 5HT3, or 5-HT3 receptor, is a ligand-gated ion channel belonging to the Cys-loop superfamily. Upon serotonin binding, the channel opens, allowing cations (Na+, K+, Ca2+) to flow, leading to neuronal depolarization. It is involved in emesis, GI motility, and neurodevelopment. Selective antagonists are used to prevent chemotherapy-induced nausea and vomiting.
- Other names
- 5HT3 receptor5-hydroxytryptamine receptor 3
02
Mechanism of action
Antagonists block serotonin binding at 5‑HT₃ receptors, preventing ion channel opening and subsequent neuronal depolarization.
03
Biological functions
Fast excitatory neurotransmissionRegulation of GI motilityEmesisNeurodevelopment
04
Disease associations
EmesisGastrointestinal disordersAnxietyPsychiatric disorders
05
Interacting drugs
Ondansetron
6 more in the full profile.
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