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Target intelligence / Profile preview
Serotonin Receptor 5HT6 (5-HT6 Receptor)
- Target
- 5-HT6 Receptor
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor
01
Overview
The 5-HT6 receptor is a subtype of serotonin (5-hydroxytryptamine, 5-HT) receptors, which are G protein-coupled receptors (GPCRs) primarily found in the central nervous system. It is encoded by the HTR6 gene. The receptor modulates cognition, learning, memory, and influences multiple neurotransmitter systems. Its unique distribution pattern suggests it plays critical roles specifically related to higher-order brain functions.
- Other names
- 5-hydroxytryptamine receptor 6HTR6
02
Mechanism of action
Gs protein activation, increased adenylate cyclase activity, increased cAMP production. Antagonists increase glutamatergic and cholinergic neurotransmission, facilitate dopamine and norepinephrine release. Agonists enhance GABAergic signaling.
03
Biological functions
Signal transductionModulation of cognitionModulation of memoryRegulation of appetiteRegulation of neurotransmitter releasecAMP production
04
Disease associations
Alzheimer's diseaseDementiaObesityDepressionAnxiety disordersOCD
05
Safety considerations
Clinical trials for dementia failed efficacy endpointsPotential for off-target effects due to modulation of multiple neurotransmitter systems
06
Interacting drugs
Latrepirdine
7 more in the full profile.
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