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Target intelligence / Profile preview
Serotonin Receptor 6 (5-HT6R)
- Target
- 5-HT6R
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
The serotonin receptor 6 (5-HT6R) is a G protein-coupled receptor that binds serotonin. It is primarily expressed in the brain, particularly in the striatum, amygdala, nucleus accumbens, hippocampus, and cortex. Activation of 5-HT6R stimulates adenylate cyclase, increasing cAMP levels. It plays roles in cognition, memory, motor control, emotional regulation, and appetite. Selective ligands are being explored as potential therapeutics for cognitive disorders and obesity due to its CNS-restricted expression profile.
- Other names
- 5-hydroxytryptamine receptor 65HTR6HTR6
02
Mechanism of action
Activation by serotonin stimulates adenylate cyclase activity, leading to increased intracellular cAMP levels.
03
Biological functions
Signal transductionExcitatory neurotransmissionMotor controlEmotional regulationCognitionMemory formationAppetite regulationIngestive behavior
04
Disease associations
Cognitive disordersObesityNeurological diseasesNeuropsychiatric disorders
05
Safety considerations
Potential for off-target effects due to interactions with other receptors.Therapeutic challenges in developing highly selective ligands.
06
Interacting drugs
Atypical antipsychotic drugs
2 more in the full profile.
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