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Target intelligence / Profile preview
Serotonin Receptor 7 (None)
- Target
- None
- Molecular classification
- GPCR, G protein-coupled receptor
01
Overview
The serotonin receptor 7 (5-HT7 receptor) is a G protein-coupled receptor activated by serotonin. It is involved in mood regulation, circadian rhythms, sleep, learning, memory, and smooth muscle relaxation. It primarily couples to Gs proteins, leading to increased cAMP and PKA activation, but can also couple to Gα12 proteins. Dysregulation of 5-HT7 signaling has been linked to neuropsychiatric disorders and other diseases, making it a potential therapeutic target.
- Other names
- 5-hydroxytryptamine receptor subtype 7HTR7
02
Mechanism of action
Gs protein activation, leading to increased cAMP and PKA activation. Gα12 activation leading to cytoskeletal modulation via Rho-GTPases.
03
Biological functions
Mood regulationCircadian rhythm regulationSleep regulationLearning and memorySmooth muscle relaxationSignal transduction
04
Disease associations
Neuropsychiatric disordersAutism spectrum disorderMood disordersDepressionInflammatory bowel diseasesCancerVisceral painHyperalgesia
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