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Target intelligence / Profile preview
Serotonin Receptor 7 Subunit (5-HT7 Receptor)
- Target
- 5-HT7 Receptor
- Molecular classification
- G protein-coupled receptor, GPCR, Class A rhodopsin-like receptor, Receptor
01
Overview
The serotonin receptor 7 subunit (5-HT7 receptor) is a G protein-coupled receptor activated by serotonin. It plays a role in various physiological processes, including circadian rhythms, mood regulation, learning and memory, and gastrointestinal motility. It is a therapeutic target for neuropsychiatric and gastrointestinal disorders.
- Other names
- 5-Hydroxytryptamine Receptor 7HTR7
02
Mechanism of action
Gs protein activation, increased adenylate cyclase activity, increased cAMP levels, PKA activation, ERK/MAPK cascade activation, modulation of Rho family GTPases
03
Biological functions
Signal transductionRegulation of circadian rhythmsModulation of mood and emotional behaviorInfluence on learning and memoryRegulation of sleepBrain network developmentSynaptic plasticitySmooth muscle relaxationRegulation of gastrointestinal motilityPain perception
04
Disease associations
DepressionAnxiety disordersSchizophreniaCognitive impairmentsIrritable Bowel Syndrome (IBS)
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