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Target intelligence / Profile preview
Serotonin Receptor-Ion Channel Complex (5-HT3 Receptor)
- Target
- 5-HT3 Receptor
- Molecular classification
- Ligand-gated ion channel, Receptor
01
Overview
The serotonin receptor-ion channel complex, primarily referring to the 5-HT3 receptor, is a unique ligand-gated ion channel that mediates rapid excitatory neurotransmission. Upon serotonin binding, it opens a cation-selective pore, leading to neuronal depolarization. It plays a role in nausea/vomiting reflexes, gut motility, and modulation of pain pathways, with antagonists used as antiemetics.
- Other names
- 5-Hydroxytryptamine Receptor 35-HT3Serotonin-gated ion channel
02
Mechanism of action
Ligand binding opens a cation-selective pore, leading to neuronal depolarization and excitation.
03
Biological functions
NeurotransmissionSynaptic transmissionIon channel activityRegulation of gut motilityModulation of pain pathways
04
Disease associations
NauseaVomitingIrritable Bowel Syndrome (IBS)AnxietyDepression
05
Safety considerations
QT prolongation (with some antagonists)Constipation (with some antagonists, particularly alosetron)Serotonin syndrome (rare, with concomitant serotonergic drugs)
06
Interacting drugs
Ondansetron
4 more in the full profile.
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