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Serotonin Receptor Subtype 1D (None)

Target: None
Molecular classification: G protein-coupled receptor, GPCR, 7TM receptor, Class A GPCR, Receptor

Overview

The serotonin receptor subtype 1D (5-HT1D), encoded by the HTR1D gene, is a G protein-coupled receptor that belongs to the 5-HT₁ family of serotonin receptors. It is primarily expressed in the central nervous system and mediates various physiological functions including modulation of locomotion, anxiety, and vasoconstriction. Triptans, used for acute migraine treatment, exert their effects by activating this receptor to induce cranial vasoconstriction.

Other names: 5-hydroxytryptamine receptor 1D5-HT1DHTR1D

Mechanism of action

Gi/Go protein coupling leading to inhibition of adenylyl cyclase activity and decreased cellular cAMP levels

Biological functions

Signal transductionCNS modulationVasoconstrictionNeurotransmission modulation

Disease associations

MigraineAnxiety

Safety considerations

Vasoconstriction (potential cardiovascular risks with triptans)

Interacting drugs

Triptans

2 more in the full profile.

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