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Target intelligence / Profile preview
Serotonin Receptor Subtype 2 (5-HT₂ receptor family)
- Target
- 5-HT₂ receptor family
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
The serotonin receptor subtype 2, commonly referred to as the 5-HT₂ receptor family, consists of three main subtypes: 5-HT₂A, 5-HT₂B, and 5-HT₂C. These receptors are part of the larger serotonin (5-hydroxytryptamine or 5-HT) receptor family and are classified as G protein-coupled receptors (GPCRs), specifically coupling to Gq/G11 proteins. They mediate excitatory neurotransmission by increasing intracellular levels of inositol triphosphate (IP₃) and diacylglycerol (DAG).
- Other names
- 5-HT2 receptor family5-Hydroxytryptamine Receptor Subtype 2Serotonin 2 receptors
02
Mechanism of action
Agonism or antagonism at 5-HT₂ receptor subtypes, modulation of IP₃/DAG signaling cascade
03
Biological functions
NeurotransmissionSignal transductionCognitionMood regulationAppetite controlCardiac function
04
Disease associations
DepressionSchizophreniaMood disordersDrug-induced valvulopathy
05
Safety considerations
Drug-induced valvulopathy (5-HT₂B)Psychedelic effects (5-HT₂A)Cardiac side effects
06
Interacting drugs
LSD
3 more in the full profile.
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