Target intelligence / Profile preview

Serotonin receptor subtype 2A (5-HT2A)

Target: 5-HT2A
Molecular classification: G protein-coupled receptor, GPCR, Receptor, Class A GPCR

Overview

The 5-HT2A receptor is a G protein-coupled receptor that plays a key role in regulating cortical function, cognition, learning, memory formation, spatial cognition, mood regulation, and perception. It is also involved in vascular function, including vasoconstriction and inflammation. Abnormalities in 5-HT2A receptor function are linked to several neuropsychiatric disorders, including schizophrenia, depression, and anxiety. It is a target for hallucinogens and atypical antipsychotics.

Mechanism of action

Agonism, Antagonism, Inverse agonism

Biological functions

NeurotransmissionSignal transductionCognitionLearningMemory formationSpatial cognitionMood regulationPerceptionVasoconstrictionInflammationWound healing

Disease associations

SchizophreniaDepressionAnxietyObsessive-compulsive disorderNeuropsychiatric disorders

Safety considerations

HallucinationsPotential for paradoxical downregulationComplicated selective drug design efforts due to high sequence identity with related subtypes

Interacting drugs

LSD

3 more in the full profile.

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