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Target intelligence / Profile preview
Serotonin Receptor Subtype 2C (5-HT2C)
- Target
- 5-HT2C
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor
01
Overview
The serotonin receptor subtype 2C (5-HT2C) is a G protein-coupled receptor (GPCR) that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). It plays a critical role in modulating various central nervous system functions, including appetite, anxiety, and mood. Dysregulation is implicated in psychiatric disorders and metabolic conditions, making it a therapeutic target.
- Other names
- 5-hydroxytryptamine receptor 2CHTR2C
02
Mechanism of action
Agonist or antagonist binding modulates downstream signaling pathways, including Gq/11-PLCβ-IP3/DAG and other pathways (e.g., ERK, nitric oxide).
03
Biological functions
Signal transductionAppetite/satiety controlAnxiety modulationStress responseSleep regulationMotor neuron activity
04
Disease associations
DepressionSuicidal behaviorObesity/metabolic disordersSubstance use disorders/addiction vulnerabilitySpasticitySchizophrenia
05
Interacting drugs
Lorcaserin
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