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Target intelligence / Profile preview
Serotonin Receptor Subtype 5-HT1A (5-HT1A)
- Target
- 5-HT1A
- Molecular classification
- G protein-coupled receptor (GPCR), Receptor
01
Overview
The serotonin 1A receptor (5-HT1A) is a subtype of serotonin receptors and a G protein-coupled receptor (GPCR). It binds serotonin and regulates mood, anxiety, cognition, and neuroendocrine function. Activation of the 5-HT1A receptor leads to neuronal inhibition and modulates hormone secretion, influencing various physiological and psychological processes. Alterations in 5-HT1A receptor function are implicated in mood disorders, making it a target for antidepressants and anxiolytics.
- Other names
- Serotonin 1A ReceptorHTR1A
02
Mechanism of action
Modulation/desensitization/upregulation/downregulation of 5-HT1A receptor activity. Typically, activation leads to Gi/o protein coupling, inhibiting adenylyl cyclase, opening potassium channels, and inhibiting calcium channels, resulting in neuronal inhibition.
03
Biological functions
Signal transductionRegulation of moodRegulation of anxietyRegulation of cognitionNeuroendocrine function modulationNeuronal inhibitionModulation of hormone secretion
04
Disease associations
Mood disordersDepressionAnxiety
05
Safety considerations
Potential for side effects associated with serotonergic modulation.Downregulation of postsynaptic 5-HT1A receptor expression due to chronic stress.Complex interplay with other neurotransmitter systems.
06
Interacting drugs
SSRIs
1 more in the full profile.
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