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Serotonin Receptor Subtype 5-HT2A (None)
- Target
- None
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor
01
Overview
The serotonin 2A receptor (5-HT2A) is a subtype of the serotonin (5-hydroxytryptamine, 5-HT) receptor family. It is a G protein-coupled receptor (GPCR), specifically coupled to the Gq/11 protein, and is considered the main excitatory serotonin GPCR in the central nervous system. The gene encoding this receptor in humans is HTR2A. It is involved in learning and memory processes, mood regulation, neurogenesis, and cortical function and cognition. Abnormalities or dysregulation are implicated in psychiatric disorders including depression, schizophrenia, drug addiction, and suicidality. Overexpression has been observed in depressed patients; downregulation occurs with chronic SSRI or atypical antipsychotic use.
- Other names
- 5-hydroxytryptamine receptor 2A5-HT2A receptorHTR2A
02
Mechanism of action
Agonism, antagonism, inverse agonism
03
Biological functions
Signal transductionLearning and memory modulationMood regulationNeurogenesisCortical function regulationCognition modulationVasoconstriction
04
Disease associations
DepressionSchizophreniaDrug addictionSuicidalityMental disorders
05
Interacting drugs
LSD
5 more in the full profile.
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