Serotonin receptor subtype 5-hydroxytryptamine receptor 4 (5-HT4 receptor)

The *serotonin receptor subtype 5-hydroxytryptamine receptor 4* (**5‑HT4**) is a member of the human serotonin receptors family encoded by the *HTR4* gene. It belongs to the class of G protein-coupled receptors that mediate cellular responses by stimulating cyclic AMP production when activated by its natural ligand serotonin (5-hydroxytryptamine). The protein is glycosylated with seven transmembrane domains typical for GPCRs.\n\nThis receptor is expressed both centrally—in brain regions such as putamen, caudate nucleus, nucleus accumbens, globus pallidus, substantia nigra—and peripherally in tissues including alimentary tract smooth muscle cells, urinary bladder, heart tissue, and adrenal glands. Its activation modulates various neurotransmitters' release influencing physiological processes like cognition, mood regulation, gastrointestinal motility control through prokinetic activity.\n\nMultiple splice variants exist with isoform-specific internalization properties. Pharmacologically it serves as an important therapeutic target especially for disorders involving impaired gut motility where selective agonists can enhance intestinal peristalsis[1][2][3][4].

Other names

5-Hydroxytryptamine receptor 4HTR4serotonin type 4 receptor

Drugs targeting the 5‑HT4 receptor typically act as agonists that stimulate the GPCR to increase intracellular cAMP levels leading to enhanced neurotransmitter release and increased gastrointestinal motility. This activation modulates both peripheral functions like gut movement and central processes related to neurotransmission.