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Serotonin Receptors 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C (5-HT1A/1B/2A/2C)
- Target
- 5-HT1A/1B/2A/2C
- Molecular classification
- G protein-coupled receptor
01
Overview
Serotonin receptors (5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C) are G protein-coupled receptors that mediate the effects of serotonin in the central and peripheral nervous systems. They regulate a wide range of physiological processes including mood, cognition, pain, appetite, sleep, and more. 5-HT1A/1B are Gi/o coupled, leading to neuronal inhibition, while 5-HT2A/2C are Gq/11 coupled, leading to excitatory responses. Many psychiatric drugs target these receptors to treat depression, anxiety, schizophrenia, and other disorders.
- Other names
- 5-hydroxytryptamine receptor 1A5-hydroxytryptamine receptor 1B5-hydroxytryptamine receptor 2A5-hydroxytryptamine receptor 2CHTR1AHTR1BHTR2AHTR2C
02
Mechanism of action
Agonism, partial agonism, antagonism, inverse agonism at serotonin receptor subtypes. Modulation of cAMP and IP3/DAG signaling pathways.
03
Biological functions
NeurotransmissionSignal transductionMood regulationAnxiety modulationAppetite regulationSleep regulationThermoregulationAggression modulationLearning and memoryCognitionPain perceptionHormone secretion
04
Disease associations
DepressionAnxiety disordersSchizophreniaMigraineAppetite disordersGastrointestinal motility issuesNeurodegenerative diseasesMood disorders
05
Safety considerations
Hallucinogenic effects (5-HT2A)Potential for drug interactionsSide effects associated with altered neurotransmitter signaling
06
Interacting drugs
Buspirone
4 more in the full profile.
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