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Serotonin reuptake
- Molecular classification
- Transporter process, Membrane transport
01
Overview
Serotonin reuptake regulates serotonergic signaling intensity/duration by clearing excess neurotransmitter from synapses. It is mediated primarily by SERT protein and targeted pharmacologically by SSRIs. Modulation is central to antidepressant action and relevant for multiple psychiatric conditions.
- Other names
- 5-HT reuptake
02
Mechanism of action
Inhibition of serotonin transporter (SERT), leading to increased serotonin levels in the synapse.
03
Biological functions
Regulation of serotonergic signalingNeurotransmitter clearanceSynaptic transmission termination
04
Disease associations
Major depressive disorderAnxiety disordersObsessive-compulsive disorderPanic disorder
05
Safety considerations
Side effects during initial treatment phasesVariable response among individuals
06
Interacting drugs
Fluoxetine
2 more in the full profile.
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