Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Serotonin Synthesis (N/A)
- Target
- N/A
- Molecular classification
- Metabolic Pathway
01
Overview
Serotonin synthesis refers to the biochemical process by which the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) is produced from its precursor, the amino acid L-tryptophan. This process is essential for normal functioning of both the central nervous system and peripheral tissues. It involves two key enzymatic steps: the conversion of L-tryptophan to 5-hydroxytryptophan (5-HTP) by tryptophan hydroxylase (TPH), followed by the decarboxylation of 5-HTP to serotonin by aromatic amino acid decarboxylase (AAAD). The pathway is regulated by tryptophan availability and dysregulation is implicated in mood disorders and other conditions.
- Other names
- 5-Hydroxytryptamine Synthesis5-HT Synthesis
02
Mechanism of action
N/A
03
Biological functions
Neurotransmitter biosynthesisRegulation of moodRegulation of appetiteRegulation of sleepRegulation of gastrointestinal motilityPlatelet aggregation
04
Disease associations
Mood disordersAnxiety disordersGastrointestinal disordersCarcinoid syndrome
05
Safety considerations
Excess serotonin production can occur with certain tumors.Dysregulation can lead to neuropsychiatric disorders.
06
Interacting drugs
p-Chlorophenylalanine
1 more in the full profile.
07
Biomarkers
5-Hydroxyindoleacetic acid (5-HIAA)
Beyond the preview
Go deeper on Serotonin Synthesis (N/A).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Serotonin Synthesis (N/A).