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Target intelligence / Profile preview
Serotonin Transporter Protein SLC6A4 (SERT)
- Target
- SERT
- Molecular classification
- Transporter, Sodium:neurotransmitter symporter
01
Overview
The serotonin transporter, also known as SLC6A4, SERT, or 5-HTT, is an integral membrane protein responsible for the reuptake of serotonin (5-hydroxytryptamine, 5-HT) from the synaptic cleft back into presynaptic neurons. This process terminates serotonergic signaling and recycles serotonin in a sodium-dependent manner. The transporter is essential for maintaining serotonin homeostasis in both the central nervous system and peripheral tissues.
- Other names
- SLC6A45-HTTSodium-dependent serotonin transporter
02
Mechanism of action
Inhibition of serotonin reuptake
03
Biological functions
Termination of serotonergic signalingSerotonin reuptakeRegulation of blood serotonin levelsModulation of mucosal serotonin levels
04
Disease associations
Major depressive disorderAnxiety disordersObsessive-compulsive disorderSubstance use disordersSudden infant death syndrome (SIDS)Aggressive behavior in Alzheimer’s diseasePost-traumatic stress disorder (PTSD)Depression
05
Safety considerations
Reduced SSRI efficacy based on genetic polymorphismsPotential for adverse effects with SSRIs
06
Interacting drugs
Selective serotonin reuptake inhibitors (SSRIs)
3 more in the full profile.
07
Biomarkers
SLC6A4 repeat length polymorphism (long vs short allele)rs25531 variant
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