Serpin family B member 8 pseudogene 1 (SERPINB8P1)

Serpin family B member 8 pseudogene 1 (SERPINB8P1) is a human pseudogene belonging to the serpin superfamily, specifically within clade B8 (ovalbumin-related serpins)[2][4]. Unlike functional serpin genes, a pseudogene such as SERPINB8P1 does not encode an active protein, and no confirmed biological role, pathway, or disease association has been reported in the biomedical literature[2][4]. The nomenclature and reported aliases are derived from its sequence homology to protease inhibitors of the serpin family, characterized by a conserved serpin domain and a common serpin fold[3][6]. However, being a pseudogene, SERPINB8P1 does not act as a typical therapeutic target such as an enzyme, receptor, transporter, or signaling molecule. There is some confusion in the literature and databases regarding the aliases because similar names are used for active serpin family members (such as SERPINB11 or SERPINB8), but SERPINB8P1 itself is recorded as a nonfunctional (pseudogenic) locus[2][4]. No drugs, biomarkers, reported biological functions, or therapeutic safety issues are attributed to SERPINB8P1. As such, it is not considered a valid therapeutic target. If a functional target is intended, one should evaluate genes such as SERPINB8 or other non-pseudogene serpins. Summary: - SERPINB8P1 is a pseudogene corresponding to a member of the serpin superfamily, but with no known functional protein product or biological function; it is not a therapeutic target[2][4]. - The name and aliases are often confused with active serpin proteins, but this locus is confirmed as noncoding and nonfunctional. - is_incorrect: true — The query refers to a pseudogene, which is not a relevant molecular target for therapeutics. *If you seek information on an active serpin family protein target, verifying the HGNC symbol or gene ID and searching for the protein-coding gene (e.g., SERPINB8 or SERPINB11) is recommended.*

Other names

PI8L1SERPINB11SERPINBP1protease inhibitor 8 (ovalbumin type)-like 1serine (or cysteine) proteinase inhibitor, clade B (ovalbumin) pseudogene 1serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 11serpin peptidase inhibitor, clade B (ovalbumin) pseudogene 1serpin peptidase inhibitor, clade B8 (ovalbumin) pseudogene 1